Romanian Society of Pharmaceutical Sciences
 

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CURRENT STATUS AND FUTURE PERSPECTIVES IN THE MANAGEMENT OF PREMATURE EJACULATION – A REVIEW OF THE LITERATURE

RAZVAN MULTESCU 1#, OCTAV GINGHINĂ 2#*, BOGDAN GEAVLETE 1#, PETRISOR GEAVLETE 1#, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU 3#, MARA GEORGESCU 4#, VIOLETA BOJINCA 5#, DRAGOS GEORGESCU 1#

1.Department of Urology, ”Sf. Ioan” Hospital, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 13 Vitan-Barzesti Street, 042122, Bucharest, Romania
2 .Department of Oncological Surgery, ”Sf. Ioan” Hospital, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 13 Vitan-Barzesti Street, 042122, Bucharest, Romania
3 .Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
4 .Veterinary Medicine Faculty of Bucharest, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Mărăşti Blvd, 011464, Bucharest, Romania
5 .Department of Internal Medicine and Reumatology, “Sf. Maria” Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 37-39 Ion Mihalache Boulevard, 011172, Bucharest, Romania

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Today, new data are emerging regarding the etiology of premature ejaculation (PE), generating also new therapeutic alternatives. Behavioral therapy and sexual counseling, application of topical agents, selective serotonin reuptake inhibitors, tricyclic antidepressants, tramadol, phosphodiesterase type 5 inhibitors, alpha-blockers, oxytocin antagonists or interventional treatment (circumcision, frenulotomy, selective resection of dorsal penile nerves, penile hyaluronic acid injections) are among the therapeutic options proposed and applied for this dysfunction. Some of these alternatives are “off-label” or even still experimental.