Romanian Society of Pharmaceutical Sciences
 

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COMPATIBILITY STUDY OF FOUR BINARY COMBINATIONS OF ACTIVE INGREDIENTS FOR DERMAL FILM FORMING SYSTEMS

AURA RUSU 1, ADRIANA CIURBA 2, MAGDALENA BÎRSAN 3*, PAULA ANTONOAEA 2, BLANKA SZÉKELY-SZENTMIKLÓSI 1, IBOLYA FÜLÖP 4, GIORGIANA-ANDREEA PASCU 5, NICOLETA TODORAN 2

1.Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
2.Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
3.Pharmaceutical Technology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania
4.Toxicology and Biopharmacy, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
5.Regulatory Affairs Department, Gedeon Richter România, Târgu Mureş, Romania

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Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures - ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4) – combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and molecular modelling (MM) were used to characterise and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chemical interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures. Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations.