Romanian Society of Pharmaceutical Sciences
 

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COMPARATIVE DICLOFENAC DETECTION FOR CHRONIC TOXICITY LEVELS USING WATER SOLUBLE Zn-METALLOPORPHYRIN, GOLD NANOPARTICLES AND THEIR HYBRID

ANCA PALADE 1, ANCA LASCU 1*, IONELA FRINGU 1, LUMINITA SALAGEANU 2, DANA VLASCICI 3, MIHAELA BIRDEANU 4, EUGENIA FAGADAR-COSMA 1

1.Institute of Chemistry Timisoara of Romanian Academy, M. Viteazul Ave. 24, 300223, Timișoara, Romania,
2.Health Insurance House Timis, Corbului Street 4, 300239-Timișoara, Romania
3.West University of Timisoara, Faculty of Chemistry-Biology-Geography, Pestalozzi Street 16, 300115, Timișoara, Romania,
4.National Institute for Research and Development in Electrochemistry and Condensed Matter, 1 Plautius Andronescu Street, 300224, Timișoara, Romania

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The optical detection of chronic toxicity levels of diclofenac were comparatively investigated using novel nanostructured materials, such as: a water soluble metalloporphyrin: Zn(II)-tetra-(4-N-methyl-4-pyridyl)porphyrin tetrachloride (ZnTMePyP), tailored size spherical gold nanoparticles (n-Au) of 15 - 20 nm, and the hybrid nanomaterial (ZnTMePyP/n-Au) formed between them. After spectroscopic and microscopic analyses, it can be stated that the water soluble Zn-porphyrin alone can detect diclofenac in a larger domain of concentration (2.57 x 10-5 - 14.15 x 10-5 mol/L) than the hybrid formed between the metalloporphyrin and n-Au and that the gold nanoparticles alone are not capable of diclofenac detection.