Romanian Society of Pharmaceutical Sciences
 

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CHALLENGES AND LIMITATIONS IN DEVELOPING AN ANIMAL MODEL OF EPIDERMOLYSIS BULLOSA ACQUISITA: A MINIREVIEW

RAMONA DANIELA PANĂ 1#, CRISTINA DEHELEAN 2#, IULIA PÎNZARU 2*, IASMINA MARCOVICI 2, SEBASTIAN SIMU 2, ZORIN CRĂINICEANU 1, ALEXANDRA ENACHE 1

1“Victor Babeș” University of Medicine and Pharmacy Timișoara, Faculty of Medicine, 2 Eftimie Murgu Square, 300041 Timișoara, Romania
2“Victor Babeș” University of Medicine and Pharmacy Timișoara, Faculty of Pharmacy, 2 Eftimie Murgu Square, 300041 Timișoara, Romania

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Epidermolysis bullosa acquisita (EBA) is a rare autoimmune pathology that affects the skin and the mucous membranes, presenting as clinical signs skin fragility, cutaneous vesicle and bullae, blisters, erosions with residual scarring and milia formation. Despite the advances recorded in the field of EBA pathogenesis molecular mechanism, diagnostic and therapeutically approaches, this topic is far from being elucidated. The present study aimed to offer a comprehensive overview of the advances recorded in the field of EBA in terms of animal murine models, key players in understanding EBA, highlighting the challenges and limitations encountered during the development of this type of models.