Romanian Society of Pharmaceutical Sciences
 

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BIOLOGICAL EVALUATION OF NEW 2-PHENETHYLBENZOYL THIOUREA DERIVATIVES AS ANTITUBERCULOSIS AGENTS

ECATERINA STRATAN 1, NADEJDA ŢURCAN 1, VALERIU CRUDU 1, ELENA ROMANCENCO 1, TAMARA COTELEA 2, GEORGE MIHAI NIŢULESCU 3*, CORNEL CHIRIŢĂ 3, LAURENŢIU MORUŞCIAG 3

1.“Chiril Draganiuc” Microbiology & Morphology Laboratory Phthisiopneumology Institute, 13 C. Vârnav Street, Chișinău, Republic of Moldova
2.“Nicolae Testemiţanu” State University of Medicine and Pharmacy, Faculty of Pharmacy, 165 Ștefan cel Mare și Sfânt Boulevard, Chișinău, Republic of Moldova
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
*corresponding author: nitulescu_mihai@yahoo.com

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In the search to find new therapeutically solutions for the tuberculosis treatment, we designed and synthesized several thiourea derivatives. We evaluated the effect on various strains of Mycobacterium tuberculosis and the acute toxicity on mice. We also performed an in silico molecular docking study in order to analyse possible interactions with certain bacterial molecular targets. All tested compounds showed a good tuberculostatic effect, no acute toxicity in mice and optimal predicted protein-ligand complex conformations, being promising lead molecules for the development of future thiourea derivatives.