Romanian Society of Pharmaceutical Sciences
 

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BIOCHEMICAL PARAMETERS CHANGES INDUCED BY LEAD EXPOSURE

RADU CIPRIAN ŢINCU1*, DANA TOMESCU2,3, LAURENŢIU COMAN3,4, RADU ALEXANDRU MACOVEI1,3

1.Clinical Emergency Hospital Bucharest, Critical Care Toxicology Unit, Bucharest, Romania
2.”Fundeni” Clinical Institute Bucharest, Romania
3.”Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
4.Physiology Department, Faculty of Pharmacy Bucharest, Romania

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Lead exposure is still present in adult life, mainly due to work place circumstances, although sustained measures had been assessed to reduce environmental emissions. The aim of present study was to determine biochemical and haematological changes in individuals suffering from lead exposure in a particular population group. Patients in lead exposure group had significantly lower haemoglobin values than controls (p = 0.015), and higher values for gamma-glutamyl transferase and alkaline phosphatase (p = 0.003 and p = 0.002, respectively).