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AUTISM SPECTRUM DISORDER – THE POSSIBLE TRIGGER OF PHARMACOLOGICAL INTERVENTIONS USED IN INFERTILITY TREATMENTS OR DURING PREGNANCY

VALENTIN NICOLAE VARLAS 1,2#, OVIDIU PENEȘ 1,3*, ROXANA GEORGIANA VARLAS 2, DRAGOȘ CREȚOIU 1, ANNE-MARIE CIOBANU 1,4#, NICOLAE SUCIU 1, ANCA POP 1,4, BRUNO ȘTEFAN VELESCU 4, CORA ZETU 1

1“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, 011132, Bucharest, Romania
3Department of Intensive Care, University Clinical Hospital, 050098, Bucharest, Romania
4Faculty of Pharmacy, 020956, Bucharest, Romania

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The prescription of drugs for the treatment of infertility or during pregnancy has seen a sharp increase in recent years. The study aimed to review the main drugs used to evaluate the balance of benefits/risks of preconception during infertility treatment or during pregnancy. A 10-year PubMed database was searched to assess the association between medication use and offspring health outcomes. Careful analysis of pharmacovigilance reports regarding the potential risk of certain classes of drugs administered during infertility treatments or during pregnancy and ASD is the main strategy regarding the appropriate neurodevelopment of the offspring.