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ASIAN SWAMP EEL (MONOPTERUS ALBUS) OIL AND VITAMIN D3 EMULSION AS NOVEL APPROACH TO IMPROVE LIPID PROFILES AND GLYCEMIC CONTROL IN RAT MODEL

YULIA YUSRINI DJABIR 1*, AMANDA IRNA SIRAPPA 1, SETRI WIRAWATI TODAN 1, BETHANIA OCTARESYA MUSTAMU 1, FIKA AGALIA KHAIRUNNISA 1, ISMAIL ISMAIL 2

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Asian swamp eel (Monopterus albus) oil and vitamin D3 have demonstrated promising antihyperlipidemic and antihyperglycemic properties. This study aimed to formulate an emulsion combining swamp eel oil and vitamin D3 (EVD) and evaluate its effects on cholesterol levels and blood glucose in rats treated with a high-fat diet (HFD). Eel powder was extracted, and the oil was emulsified with vitamin D3 and three surfactant agents to form a self-emulsifying drug delivery system (SEDDS). Twenty-five male rats were assigned into five groups: standard diet (SD), HFD, HFD with EVD (1 mL or 2 mL), and HFD with simvastatin (SVT). Treatments were administered daily for 30 days, followed by total cholesterol (TC), blood glucose (BG), and alanine aminotransferase (ALT) level measurements. The resulting EVD emulsion was clear and exhibited high stability. In an animal model, EVD significantly reduced TC, improved glycemic control, and stabilised ALT levels in HFD-fed rats compared to the untreated HFD group (p < 0.05). These findings indicate that EVD may offer therapeutic benefits for managing hyperlipidemia and glycemic dysregulation associated with high-fat diets.