Romanian Society of Pharmaceutical Sciences

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ANTIOXIDANT, ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF TANACETUM VULGARE, TANACETUM CORYMBOSUM AND TANACETUM MACROPHYLLUM EXTRACTS

BIANCA IVĂNESCU 1, CRISTINA TUCHILUȘ 2*, ANDREIA CORCIOVĂ 3, CRISTINA LUNGU 1, COSMIN TEODOR MIHAI 4, ANA-MARIA GHELDIU 5, LAURIAN VLASE 5

1.Department of Pharmaceutical Botany, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
2.Department of Microbiology, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
3.Department of Drugs Analysis, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, Iași, Romania
4.Advanced Centre for Research and Development in Experimental Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 9 Kogălniceanu Street, Iași, Romania
5.Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, Cluj-Napoca, Romania
*corresponding author: [email protected]

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The aim of this study was the evaluation of antioxidant, antimicrobial and cytotoxic activity of three Tanacetum species from Romanian flora and the identification of biologically active compounds in the analysed species. T. vulgare and T. corymbosum showed antioxidant activity in correlation with the total phenolic content of the extracts. All three species exhibited antimicrobial effect against the tested Gram-positive bacteria and fungi, and manifested strong cytotoxic activity against both cancer (HeLa) and healthy (Vero) cell lines. The chemical analyses allowed the identification of common phytosterols and many flavonoids, some reported for the first time: casticin in T. vulgare, eupatilin, casticin, acacetin, quercitrin and isoquercitrin in T. macrophyllum, eupatorin, apigenin and quercitrin in T. corymbosum. It is possible that the numerous flavonoids found in these species to contribute to the pharmacological actions of the extracts.