ANTIMICROBIAL SUSCEPTIBILITY ANALYSIS OF ESCHERICHIA COLI, STREPTOCOCCUS SPP. AND KLEBSIELLA SPP.: RETROSPECTIVE DATA FROM A MULTIDISCIPLINARY HOSPITAL IN BUCHAREST (2021 – 2024)
SORINA HÎNCU 1,2, MIRUNA-MARIA APETROAEI 1*, ANDREEA LETIȚIA ARSENE 1,3, MIHAELA CRISTINA NEGULESCU 1,2, ADRIANA TĂEREL 1, MANUELA GHICA 1, DENISA IOANA UDEANU 1,3
1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2 Fundeni Clinical Institute, 258 Fundeni Street, 022328, Bucharest, Romania
3 “Marius Nasta” Institute of Pneumology, 90 Viilor Street, 050159, Bucharest, Romania
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Antimicrobial resistance is one of the most critical challenges in modern medical practice, limiting the effectiveness of treatments and increasing the risk of complications. In this context, constant monitoring of bacterial susceptibility profiles becomes necessary for guiding empiric therapy and optimising antibiotic stewardship strategies. This retrospective observational study was conducted between 2021 and 2024 at the Fundeni Clinical Institute. Escherichia coli, Escherichia coli ESBL-positive, Streptococcus spp. and Klebsiella spp. strains isolated from invasive biological products were analysed. Susceptibility to antibiotics was assessed according to EUCAST standards, and the overall level of resistance was quantified using the mean antibiotic resistance index (MARI). E. coli showed a favourable susceptibility profile, whereas ESBL-positive strains showed a progressive increase in MARI values. Klebsiella pneumoniae had the highest MARI levels, especially in blood and urine cultures. In contrast, Streptococcus spp. maintained a low level of resistance in all sample types analysed. The results support the need for continuous adjustment of therapeutic protocols according to local resistance trends and emphasise the importance of close collaboration between the microbiology laboratory, prescribing physicians, infectious disease physicians and clinical pharmacists for effective infection control.
