Romanian Society of Pharmaceutical Sciences

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ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF IPOMOEA HEDERACEA

MUHAMMAD ZIA-UL-HAQ1, SHAKEEL AHMAD2, MILAN S. STANKOVIC3, MUHAMMAD TAUSEEF SULTAN4, IMRAN IMRAN5, VICTOR VELTER6, DIANA BADIU7, STELA HALICHIDIS8, TONY HANGAN7*

1.The Patent Office, Kandawala Building, M.A. Jinnah Road Karachi, Pakistan
2.Department of Agronomy, Bahauddin Zakariya University , Multan 60800 , Pakistan
3.Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Street Radoja Domanovića No. 12, Kragujevac 34000, Serbia
4.Department of Food Science, Bahauddin Zakariya University, Multan- 60800, Pakistan
5.Department of Pharmacology, Bahauddin Zakariya University, Multan- 60800, Pakistan
6.Scientometrics Office, UESFISCDI, Bucharest 010362, Romania
7.Faculty of Medicine, Ovidius University of Constanta 900470, Romania
8.Clinical Infectious Diseases Hospital Constanta 900708, Romania

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Research on antimicrobial and anti-oxidant activity from plant sources is increasing due to positive effects on human health. However relatively little work has been done to investigate the antimicrobial and antioxidant effects of methanolic extracts from Ipomoea hederacea. In the present study methanolic extracts of leaves, flowers, stem, seed and roots from Ipomoea hederacea were evaluated using an antimicrobial assay, the determination of total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and the total antioxidant capacity. Our results suggested that methanolic extracts exhibited high antimicrobial effects when tested against various bacterial and fungal strains (i.e. B. subtilis, P. multocida, S. aureus, E. coli, A. niger, A. flavus, A. alternate and R. solani). The total phenolic content showed the highest value for stem extract (131.11±1.22 mg/g), and the lowest for root extract (74.44±1.52 mg/g). The tested extracts were able to reduce the stable DPPH radical, reaching IC50 values from 83.14±1.02 μg/mL for stem extract to 123.32±1.83 μg/mL for root extract. A positive linear correlation was observed when total phenolic content was correlated with the total antioxidant capacity. Our study sustains the fact that methanolic extracts from Ipomoea hederacea can be used as components in a range of phytochemical formulation due to their antimicrobial and antioxidant potential.