Romanian Society of Pharmaceutical Sciences

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ANTIMICROBIAL ACTIVITY OF SOME NEW Ru(III) COMPLEXES WITH QUINOLONE DERIVATIVES

VALENTINA UIVAROSI 1*, RODICA OLAR 2, MIHAELA BADEA 2, MARIANA CARMEN CHIFIRIUC 3

1.Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Street, 050663, Bucharest, Romania
3.Department of Microbiology, University of Bucharest, 1-3 Portocalelor Alley, 060101, Bucharest, Romania

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Two series of novel Ru(III) complexes with some quinolone derivatives previously synthesized and characterized were tested for their antimicrobial activity. The first series consists of chelate complexes with general formula [RuL2Cl2]Cl∙nH2O (L: norfloxacin (nf), n = 4; L: ciprofloxacin (cp), n = 3; L: enrofloxacin (enro), n = 5), while the second series is represented by complexes of general formula RuCl3L2(DMSO)m·nH2O (L: pipemidic acid (pip), m = 1, n = 2; L: enoxacin (enx), m = 1, n = 0; L: norfloxacin (nf), m = 1, n = 1; L: ciprofloxacin, m = 2, n = 2; L: enrofloxacin (enro), m = 0.5, n = 1; L: ofloxacin (of), m = 1, n = 1; L: levofloxacin (levof), m = 2, n = 8; DMSO: dimethylsulfoxide), The complexes were tested on Staphylococcus aureus methicillin resistant MRSA, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus subtilis bacterial strains and their activity was expressed as inhibition of diameter growth (mm) and as minimum inhibitory concentration, MIC (µg/mL).