Romanian Society of Pharmaceutical Sciences

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ANTIHYPERTENSIVE EFFECTS OF HIBISCUS SABDARIFFA AND ZINGIBER OFFICINALE VAR. RUBRUM EXTRACTS IN A DEOXYCORTICOSTERONE ACETATE-SALT INDUCED HYPERTENSION RAT MODEL

RANUM WANUDYA YUNAS 1, SITI IRMA RAHMAWATI 2,4, FADLINA CHANY SAPUTRI 3,4*, DWI WAHYU INDRIANI 2,4, ASEP BAYU 2,4, MASTERIA YUNOVILSA PUTRA 2,4

1 Graduate Program, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, Indonesia 16424
2 Research Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Bogor, West Java, Indonesia 16911
3 Laboratory of Pharmacology-Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, Indonesia 16424
4 National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, Indonesia 16424

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This study evaluated the antihypertensive activity of the combination of Hibiscus sabdariffa Linn (roselle) extract and Zingiber officinale var. Rubrum (red ginger) extract on deoxycorticosterone-acetate-salt (DOCA-salt) induced hypertension in rats. Thirty male SD rats were randomly divided into six groups (n = 5 per group). Hypertension was induced by administering 30 mg/kg b.w. DOCA and 2% NaCl saline for three weeks. The treatment consisted of a normotensive group, a negative control (hypertension without treatment), a positive control (4.5 mg/200 g b.w. captopril orally) and three groups receiving the roselle-red ginger extract combination (50:3.5 mg; 100:7 mg; and 200:14 mg)/300 g b.w. for two weeks. RAAS biomarkers and an inflammatory mediator were measured according to assay procedures. The blood pressure of rats treated with the roselle-red ginger combination extract decreased significantly (p < 0.05) compared to the negative control, with values approximating those of the normotensive group. Plasma renin level, serum ACE activity, plasma Ang-II level and IL-17A level also significantly declined in the combination extract group compared to the negative control group. The roselle-red ginger combination extract has antihypertensive activity due to its effects on blood pressure, RAAS biomarkers and inflammatory mediators in the hypertension model rats.