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ANTIFUNGAL ACTIVITY OF CINNAMOMUM BURMANII ESSENTIAL OIL NANOEMULSION AGAINST ASPERGILLUS NIGER AND CANDIDA ALBICANS ISOLATED FROM OTOMYCOSIS PATIENTS

DHADHANG WAHYU KURNIAWAN 1,2*, ANTON BUDHI DARMAWAN 3, FAIZAH AURELISTA OKTAVIANA 1, AJENG RIGINA MEILANDARI 1, HANIF NASIATUL BAROROH 1

1Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Jl. dr. Suparno Kampus Unsoed Karangwangkal Purwokerto, Central Java, 53123, Indonesia
2 Graduate School, Universitas Jenderal Soedirman, Jl. dr. Suparno Kampus Unsoed Karangwangkal Purwokerto, Central Java, 53123, Indonesia
3 Departement of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Jenderal Soedirman - Margono Soekarjo Hospital, Jl. dr. Gumbreg no. 1 Purwokerto, Central Java, 53147, Indonesia

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Cinnamon essential oil is a natural substance with notable antifungal properties, particularly effective against the fungi responsible for otomycosis. However, it is characterised by poor water solubility, high volatility, and susceptibility to oxidation. Furthermore, its active component, cinnamaldehyde, exhibits low bioavailability in the human body. The formulation of nanoemulsions presents a viable solution to these issues. This study aims to evaluate the diameter of the inhibition zone and the minimum inhibitory concentration (MIC) of a nanoemulsion containing Cinnamomum burmanii essential oil against Aspergillus niger and Candida albicans isolated from otomycosis patients. The antifungal efficacy of the nanoemulsion formulations against Aspergillus niger and Candida albicans was assessed using the disc diffusion and dilution methods. A 6% ketoconazole solution served as a positive control, while a nanoemulsion devoid of essential oil (F0) was employed as a negative control. Utilizing the disc diffusion method, the Cinnamomum burmanii essential oil nanoemulsion exhibited antifungal activity, with average inhibition zone diameters of 30.0 ± 8.10 mm for Aspergillus niger and 28.5 ± 3.15 mm for Candida albicans. Conversely, the dilution method revealed an average optical density (OD) value of 0.011 ± 0.00 for Aspergillus niger and 0.003 ± 0.00 for Candida albicans at a concentration of 0.06%. The antifungal potency of the Cinnamomum burmanii essential oil nanoemulsion surpasses that of the positive control, ketoconazole.