Romanian Society of Pharmaceutical Sciences

« Back to Farmacia Journal 4/2014

ANTICONVULSANT AND SEX ENHANCING EFFECTS OF IPOMOEA HEDERACEA SEEDS EXTRACT

MUHAMMAD ZIA-UL-HAQ1, MUHAMAMD RIAZ1, SHAKEEL AHMAD2, LUCICA BARBES3*, VICTOR VELTER4, DIANA BADIU5, STELA HALICHIDIS5

1.The Patent Office, Kandawala Building,M.A. Jinnah Road Karachi, Pakistan
2.Department of Agronomy, Bahauddin Zakariya University, Multan- 60800, Pakistan
3.Department of Chemistry and Chemical Engineering, Ovidius University of Constanta, 124 Mamaia Avenue, Constanta-900527, Romania
4.Scientometrics Office, UESFISCDI, Bucharest- 010362, Romania
5.Clinical Infectious Diseases Hospital Constanta-900708, Romania

Download Full Article PDF

The crude methanolic extract of Ipomoea hederacea seeds also known as ivyleaved morning glory was evaluated in terms of anticonvulsant and sex enhancing effects on albino rats. Male albino rats were divided into five groups and were orally administered Ipomoea hederacea seeds extract of 25, 50 and 75 mg/kg body weight for the three groups, the remaining two groups were used as control and reference. The Ipomoea hederacea seeds extract showed anticonvulsant effects at higher concentrations (i.e. 50 and 75 mg/kgbw). Furthermore, the evaluation of sex enhancing effects showed increased level in mount frequencies, which represents an increased libido. Our investigations have been proved to be promising in terms of future potential applications of extract as anticonvulsant and sex enhancer probably due to the presence of lysergic acid derivatives and clavine alkaloids which could be used in a range of phytochemicals composition and/or different pharmaceutical use.