Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 2/2016

ANTI-INFLAMMATORY EFFECTS OF ERYNGIUM PLANUM L. AND E. MARITIMUM L. (APIACEAE) EXTRACTS IN TURPENTINE-OIL INDUCED ACUTE INFLAMMATION IN RATS

SIMONA CONEA (SUCIU)1*, ALINA ELENA PÂRVU2, SORANA BOLBOACĂ3

1.Department of Clinical Pharmacy, “Vasile Goldiş” West University Revoluţiei Blv. 94-96, Arad, Romania
2.Department of Pathophysiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 3-5 Clinicilor Street, Cluj- Napoca, Romania
3.Department of Biostatistics, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Pasteur Street, Cluj-Napoca, Romania

Download Full Article PDF

The aim of this paper was to evaluate the effects of two 1:1 fluid extracts (FE) of Eryngium planum and E. maritimum aerial parts on acute inflammation induced by turpentine oil in rat. Results of 1:10 and 1:100 dilutions of the two extracts were compared to those from a control group treated only with sterile saline and to a group treated with diclofenac (a nonsteroidal anti-inflammatory drug – NSAID). Both tested extracts showed anti-inflammatory effects, because they lowered the circulating phagocytes proliferation and activation and decreased the nitrogen oxide (NO) synthesis. On bone marrow acute phase response, both extracts showed a very significant inhibitory action by reducing the total leukocyte number by lowering the neutrophils percentage (acute phase phagocytes).