Romanian Society of Pharmaceutical Sciences
 

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ANTI-GIARDIA ACTIVITY OF TANACETUM VULGARE FLOWERS EXTRACT ON INFECTED MICE

MARIA LUCIA MUREȘAN 1, ANAMARIA COZMA-PETRUȚ 2*, DANIELA BENEDEC 2#, CORNELIA REVNIC 2, DANIELA HANGANU 2, ELENA DINTE 2, ANAMARIA BALEA 3, ILIOARA ONIGA 2#

1“Lucian Blaga” University, Faculty of Medicine, 2A Lucian Blaga Street, 550169, Sibiu, Romania
2“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 8 V. Babeș Street, 400010, Cluj-Napoca, Romania
3University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, 3-5 Calea Mănăștur Street, 400372, Cluj-Napoca, Romania

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The Giardia duodenalis infection is considered one of the common pathologies caused by flagellated protozoa in humans, and medicinal plants are important sources of antiprotozoal agents with fewer side effects. The aim of this study was to evaluate the anti-Giardia activity of Tanacetum vulgare L. (Asteraceae), common tansy flowers hydroalcoholic extract. The experiment was conducted on mice infected with G. muris, using metronidazole and Giardiplant® (a commercial product) for comparison. After 5 days of treatment, the G. muris trophozoites count in the small intestine was significantly decreased (p < 0.01) in the group treated with T. vulgare tincture, compared to the group treated with metronidazole. The obtained results have shown that T. vulgare flowers extract has in vivo anti-Giardia effects and it can be considered a promising natural alternative for the treatment of giardiasis.