Romanian Society of Pharmaceutical Sciences
 

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AN EVALUATION OF THE ANTIINFLAMMATORY POTENTIAL OF SOME POLYHETEROCYCLIC COMPOUNDS WITH THIAZOLE RINGS IN ACUTE INFLAMMATION MODELS. PART I. VASCULAR RESPONSE

CRISTINA MOGOŞAN1, OLIVIU VOŞTINARU1*, ALINA ELENA PÂRVU2, CRISTINA POP1, VALENTIN ZAHARIA3

1Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania
2Department of Physiopathology, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania
3Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy“Iuliu Haţieganu”, RO-400012,Cluj-Napoca, Romania

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The anti-inflammatory effect of some polyheterocyclic compounds with thiazole rings in acute inflammation models was evaluated following their influence on the vascular response within the inflammatory process. The compounds possess an anti-inflammatory effect as they may decrease the inflammatory oedema induced by 10% kaolin.