Romanian Society of Pharmaceutical Sciences

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A PURIFIED EXTRACT FROM BROWN TRUFFLES OF THE SPECIES TERFEZIA CLAVERYI CHATIN AND ITS ANTIMICROBIAL ACTIVITY

ANGELA CASARICA1, MISU MOSCOVICI1*, MARWAN DAAS2, IOANA NICU3, MINERVA PANTELI3, IUKSEL RASIT3

1.Department of Pharmaceutical Biotechnologies, National Institute for Chemical Pharmaceutical Research and Development – ICCF, 112 Vitan Avenue, 031299, Bucharest, Romania
2.Department of Dental Surgery, Faculty of Dental Medicine, University of Paris – Descartes, 5 Rue Garancière, 75006 Paris, France
3.Pharmacology Department, National Institute for Chemical Pharmaceutical Research and Development – ICCF, 112 Vitan Avenue, 031299, Bucharest, Romania

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A purified aqueous extract of Terfezia claveryi Chatin brown truffles was obtained by water extraction, concentration and purification by ultrafiltration. The concentrated extract was tested for antimicrobial activity against three microorganisms: a Gram-negative bacterium (Escherichia coli ATCC 8739) and two Gram-positive bacteria (Staphylococcus aureus ATCC 6538P and Staphylococcus epidermidis ATCC 12228), using the agar diffusion method and it presented a very good activity in all three cases, with growth inhibition zones of 20.5 mm, 21 mm and 26.5 mm respectively. The brown truffle extract showed an antimicrobial activity comparable with that of 300 - 400 μg/mL and 25 μg/mL gentamicin sulphate chosen as reference, respectively.