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A NOVEL SENSITIVE AND SELECTIVE POTENTIOMETRIC SENSOR FOR RISPERIDONE DETECTION

OMER ISILDAK ^1*, AYSENUR BIRINCI ¹

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An antipsychotic drug containing risperidone can be analysed by liquid chromatographic techniques (LC) using UV-visible and fluorescence detectors. However, all developed methods based on LC are expensive, time consuming due to pre-and post-column reaction, and also not very sensitive. The preparation of micro-sized composite risperidone-sensitive sensors and their suitability as detector in a flow-injection analysis system is described. A risperidone-sensitive sensor membrane was prepared by coating a composite cocktail on the surface of the contact transducer in solid state. The composition ratio percentage for the best performance was obtained with 2.5% (w/w) active ingredient (ionophore), 67% (w/w) plasticizer, 30% (w/w) PVC, and 0.5% sodium tetraphenyl borate. The potentiometric performances of risperidone-selective sensor (selectivity constant, liner domain, detection limit, response time, pH working domain, repeatability, lifetime, and time dependent potential decay) were determined using computer controlled measurement systems in static conditions.