Romanian Society of Pharmaceutical Sciences
 

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A COMPREHENSIVE BEHAVIOURAL ASSESSMENT OF CURCUMIN’S EFFECT ON INFLAMMATORY AND NON-INFLAMMATORY PAIN IN MICE

IOANA-DANA ALEXA 1, ADINA CARMEN ILIE 1, GABRIEL PRADA 2, ANNA MARIE HERGHELEGIU 2, ANDREI LUCA 3, TUDOR ȘTEFAN ROTARU 4, ANDREI DONDAȘ 3, GABRIELA RUSU-ZOTA 5, TEODORA ALEXA-STRATULAT 3*, CĂTĂLINA-ROXANA BOHOTIN 3

1.Geriatrics Department, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700021, Iași, Romania
2 .“Ana Aslan” National Institute of Gerontology and Geriatrics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 .Advanced Research and Development Centre for Experimental Medicine (CEMEX), “Gr. T. Popa“ University of Medicine and Pharmacy, 16 Universității Street, 700021, Iași, Romania
4 .Medical Sciences III Department, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700021, Iași, Romania
5 .Pharmacology Department, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700021, Iași, Romania

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The present study aimed to assess the effect of oral curcumin administration on different types of experimental pain and to evaluate its effect on motor activity and coordination. The study was conducted on mice were divided in 4 groups and which received different doses of curcumin through gavage or olive oil (control). Tail Flick, Hot Plate, Rota Rod and Activity Cage tests were performed at baseline and 30, 60, 120, 180 and 240 minutes after administration. The most efficient dose (120 mg/kg bw) was chosen for the subsequent assessment. The group that received 120 mg/kg bw oral curcumin had an increased pain tolerance in both Tail Flick and Hot Plate tests. Curcumin had no effect on paw formalin-induced pain, but significantly decreased the pain-related behaviour in the orofacial formalin-induced pain test and in the visceral pain test. The substance had no influence on motor activity or coordination. Our study proved that curcumin administrated by gavage is effective in nociceptive, visceral and inflammatory experimental pain even after single-dose administration.