Romanian Society of Pharmaceutical Sciences
 

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A COMPARATIVE STUDY ON THE BIOLOGIC ACTIVITY OF CENTAUREA CYANUS VERSUS CALENDULA OFFICINALIS

ELEONORA MARIAN 1, LAURA GRAȚIELA VICAȘ 1, JURCA TUNDE 1, MARIANA MUREȘAN 2, ROXANA LIANA STAN 3*, BOGDAN SEVASTRE 4, ZORIȚA DIACONEASA 4, CORINA IONESCU 3, ADRIANA CORINA HANGAN 5

1.University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Street, 410028, Oradea, Romania
2.University of Oradea, Medicine and Pharmacy Faculty, Department of Preclinical Sciences, 10 1st December Square, 410068, Oradea, Romania
3.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry and Clinical Laboratory, 6 Pasteur Street, 400012, Cluj-Napoca, Romania
4.University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, Paraclinic/Clinic Department, 3-5 Calea Mănăștur Street, 400372, Cluj-Napoca, Romania
5.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Inorganic Chemistry, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania

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Considering that the therapeutic activity of Centaurea cyanus is less known, in the present study we aimed to evaluate its biological activity compared to Calendula officinalis. The alcoholic extracts from the two vegetal products were evaluated in terms of chemical composition, the concentrations being expressed in total polyphenols (gallic acid) and total flavonoids (quercetin). The studies carried out have shown the protective effect of the plant extracts against free radicals (superoxide dismutase - SOD-like activity in vivo), their antioxidant capacity (DPPH, FRAP, CUPRAC methods) and cytotoxicity assays. Centaurea cyanus possesses superior biological activities versus Calendula officinalis.