Romanian Society of Pharmaceutical Sciences

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5-ARYLAMINO-1,3,4-THIADIAZOL-2-YL ACETIC ACID ESTERS AS INTERMEDIATES FOR THE SYNTHESIS OF NEW BISHETEROCYCLIC COMPOUNDS

GEORGETA ŞERBAN*

University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga, 410028 Oradea, România

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A series of 5-arylamino-1,3,4-thiadiazol-2-yl acetic acid esters have been synthesized by the cyclization of the corresponding thiosemicarbazides with concentrated sulphuric acid followed by the esterification of the amide group. The thiosemicarbazides derivatives were obtained by nucleophilic addition of cyanoacetic acid hydrazide to different arylisothiocyanates. The newly synthesized compounds were characterized by their physical parameters and the structures were elucidated by spectral data and elemental analysis.