Romanian Society of Pharmaceutical Sciences
 

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ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN BURNS TREATMENT

DENISA IOANA UDEANU 1, MĂDĂLINA GEORGIANA ALBU KAYA 2, MIHAELA VIOLETA GHICA 3*, ȘTEFANIA MARIN 2,4, MARIA MINODORA MARIN 2,5, DURMUȘ ALPASLAN KAYA 6, LĂCRĂMIOARA POPA 3, CRISTINA DINU-PÎRVU 3

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety, 6 Traian Vuia Street, 020956, Bucharest, Romania
2 .The National Research & Development Institute for Textiles and Leather, Division of Leather and Footwear Research Institute, Department of Collagen Research, 93 Ion Minulescu Street, 031215, Bucharest, Romania
3 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physical and Colloidal Chemistry, 6 Traian Vuia Street, 020956, Bucharest, Romania
4 .University Politehnica of Bucharest, Faculty of Applied Sciences, 313 Splaiul Independentei Street, 060042, Bucharest, Romania
5 .University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, 1-7 Gheorghe Polizu Street, 011061, Bucharest, Romania
6 .“Mustafa Kemal” University, Faculty of Agriculture, Department of Field Crops, Antakya-Hatay, 31030, Turkey

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The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed anti-inflammatory drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no anti-inflammatory drug.