PREVALENCE OF HYPERURICEMIA AND THE EVIDENCE-BASED IMPACT FACTORS ON SERUM URIC ACID LEVELS
COSTEL GRIGORE 1, RAMONA GRIGORE 1, IRINA IONICĂ 1, VIOLETA POPOVICI 2*, DIMITRU LUPULIASA 1, ANA-MARIA DASCĂLU 1, BRUNO ȘTEFAN VELESCU 1, VIOREL ROBERT ANCUCEANU ¹
¹ “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Center of Mountain Economics, “Costin C. Kiritescu” National Institute of Economic Research (INCE-CEMONT),
Romanian Academy, Vatra-Dornei, Romania
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This cross-sectional health survey aimed to assess the prevalence of hyperuricemia and identify the pharmacological and an- thropometric factors influencing serum uric acid (SUA) levels in a Romanian community pharmacy setting. Data were collected from 377 participants (aged 18–89) at two pharmacies in Călărași County. Measurements included SUA, blood pressure, fasting glucose, and BMI. Multivariable linear regression with multiple imputation was used to identify predictors of SUA levels. Hyperuricemia prevalence was 40.4% among participants with measurable levels. Potent diuretics, specifically indapamide and furosemide, were strongly associated with higher SUA levels (β = 1.22, p < 0.001). Height emerged as a significant independent predictor (β = 3.72, p = 0.004). No significant protective effects were found for amlodipine or perindopril. Hyperuricemia is highly prevalent and often unrecognized in the community. Thiazide or loop diuretics and physical height are key contributors to elevated SUA. Community pharmacists are well-positioned to perform opportunistic screening to mitigate cardiometabolic risks associated with elevated uric acid.
