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PRECOMPRESSION STUDIES OF SOME MATERIALS BASED ON RIVAROXABAN DRY NANOSUSPENSIONS

CLAUDIA BENGA ¹, EMMA ADRIANA OZON ¹*, ANDREEA ROXANA UNGUREANU ² , ADINA MAGDALENA MUȘUC ³, CRISTINA ELENA DINU PÎRVU 1

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To ensure suitable powder flowability, compactability, and, implicitly, tablet quality, precompression studies are essential as- sessments carried out on tablet powder blends before final compression. Various investigations are performed on tablet formu- lation materials as part of precompression research. These analyses aim to evaluate the flow and compressibility of powder blends to determine whether their physicochemical properties meet processing requirements. This study reveals the influence of dry nanosuspension formulations on the physical characteristics of materials intended for the direct compression process. Six direct compression blends were prepared: three containing dry nanosuspensions of rivaroxaban (RIV), Poloxamer 188 (P188), and hydroxypropyl methylcellulose (HPMC), and three containing their simple physical mixtures. Various formula- tions based on microcrystalline cellulose and spray-dried lactose were analysed to evaluate their flowability and compressibility properties to determine their suitability for direct compression. It was concluded that a higher amount of HPMC and the use of the lyophilisation technique result in blends unsuitable for direct compression.