Romanian Society of Pharmaceutical Sciences
 

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ANTIOXIDANT COUMARIN-CHALCONE HYBRIDS WITH LOW ACUTE TOXICITY

SUZANA JANIĆEVIĆ 1, VIDOSLAV DEKIĆ 1*, NIKO RADULOVIĆ 2, BILJANA DEKIĆ 1 , EMILIJA PECEV-MARINKOVIĆ 2, MILENKO RISTIĆ 1, MARIJA AKSIĆ 1

1 University of Priština in Kosovska Mitrovica, Faculty of Sciences and Mathematics, Kosovska Mitrovica, Serbia
2 University of Niš, Faculty of Sciences and Mathematics, Niš, Serbia

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The synthesis of new products by combining different physiologically active structural cores is of great interest to medicinal chemists due to the potential for synergistic effects, which can result in hybrids with enhanced pharmaceutical activities. Eight coumarin-chalcone hybrids were synthesized by reacting 4-hydroxy-3-acetylcoumarin with various substituted aro- matic aldehydes. The structures of the synthesized products were fully characterized using spectral methods. Detailed as- signment of 1H- and 13C-NMR resonances was achieved through a combination of 1H- 1H COSY, NOESY, HSQC and HMBC experiments. Antioxidant activities were evaluated using the DPPH free radical scavenging assay.