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MOLECULAR PERSPECTIVES ON THE IMPACT OF INFLAMMATORY PROCESSES ON DRUG METABOLISM

OANA DANA ARCAN 1, ALEXANDRU VASINCU 1*, DANIELA-CARMEN ABABEI 1, DELIA BULEA 1, IOANA MACADAN 1, RĂZVAN-NICOLAE RUSU 1, MONICA NEAMȚU 2 , VERONICA BILD 1,3

1 Department of Pharmacodynamics and Clinical Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi,
Iasi, Romania
2 Department of Physiology. Cell and Molecular Biology, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania
3 “Olga Necrasov” Center of Anthropological and Biomedical Research, Romanian Academy, Iasi Branch, Iasi, Romania

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In the complex, well-coordinated process of inflammation, a variety of cell types and molecules cooperate in a cascading network. Numerous physiological and pathological processes are rooted in inflammation. The mechanism of inflammation comprises a number of dynamic, coordinated reactions, including cellular and vascular events and specific humoral secretions. The liver is adversely affected by proinflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumour necrosis factor. IL-6 has been shown to selectively regulate several cytochrome P450 (CYP) enzymes, including CYP3A4. Some CYPs actively contribute to inflammation by converting fatty acids into mediators that are either pro- or anti-inflammatory. Genetic variability within inflammatory transcription factors is of great interest due to its critical role in inflammatory signalling.