Romanian Society of Pharmaceutical Sciences
 

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EFFECTS OF ORAL ASPIRIN AND CALCIUM ON HEMODYNAMICS AND PLACENTAL PATHOLOGICAL CHANGES IN PATIENTS WITH PREGNANCY-INDUCED HYPERTENSION

DI ZHU 1, RU DING 2, SHENGLIN JIANG 1, ZHOUHUI YUAN 1, LIJIE LI 1*

1 Department of Obstetrics, Zhejiang Hospital, Hangzhou, 310030, Zhejiang, China
2 Department of Gastroenterology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, 310022, Zhejiang, China

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This study aimed to evaluate the effects of oral aspirin and calcium supplementation on hemodynamic parameters and placental pathology in patients with pregnancy-induced hypertension (PIH), and to assess their potential role in PIH management. A total of 210 pregnant women with a positive PIH prediction were retrospectively divided into three groups: control (n = 96), mild (n = 66), and severe (n = 48). The mild group received routine care plus vitamin C (1g/day), vitamin E (50 mg/day), and vitamin D-calcium chewable tablets (600 mg calcium + 400 IU vitamin D). The severe group received the same regimen with the addition of aspirin (100 mg/day). Hemodynamic parameters, coagulation indexes, middle cerebral artery and umbilical artery resistance indices (RI), placental histology, and clinical outcomes were assessed before treatment, after 5 weeks, and prior to delivery. Significant improvements in hemodynamic and coagulation parameters and RI values were observed post-treatment in the severe group compared to the mild group (p < 0.05). Caesarean rates and complications such as postpartum haemorrhage, placental abruption, and foetal distress were notably reduced in the severe group. Overall, oral aspirin and calcium supplementation improved maternal-foetal outcomes by enhancing hemodynamic and placental function, offering valuable guidance for the clinical management of PIH.