Romanian Society of Pharmaceutical Sciences
 

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PHYTOCONSTITUENTS EFFECTS OF TRADITIONNALY HERBES ON DISSOLUTION AND INHIBITION OF KYDNEY STONES (CAOX)

FOUZIA BELABDELLI 1,2, EL-KADI FATIMA ZOHRA 3*, SIDI AHMED BENAOULA 2, NABILA BEKHTI 1,4, ALESSANDRA PIRAS 5, ILHAM TALEB 1,2, SEKKAL-RAHAL MAJDA 1

1Djillali Liabés University, Faculty of Science Exact, Laboratory of Theoretical Chemistry of Bio- & Nano-systems, Sidi Bel Abbés, Algeria
2 Djillali Liabés University, Faculty of Medicine, Department of Pharmacy, , B.P.89, 22000, Algeria
3 Djillali Liabés University, Faculty of Natural Sciences and Life, Biology Department, Laboratory of Molecular Microbiology Health and Proteomics, Sidi Bel Abbés, Algeria
4 Mustapha Stambouli University, Faculty of Science and Technology, Department of Process Engineering, BP.305, Route Mamounia, 29000, Mascara, Algeria
5 University of Cagliari, Department of Chemical and Geological Sciences, Cittadella Universitaria, SP 8, Monserrato – Sestu km 0.700, 09042 Monserrato (CA), Italy

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Many developing countries employ medicinal plants for the treatment of kidney stone dissolution. Patients consume aqueous extracts without precise knowledge of the plant's composition. This study aimed to expand the phytochemical knowledge of traditional herbal remedies and evaluate their constituents for the dissolution and inhibition of kidney stones. The herbal plants selected were Ammi visnaga, Nigella sativa, Berberis vulgaris, Haloxylon scoparium, Atriplex halimus and Arthrophytum schmittianum. An extract of each plant was prepared by the infusion method in physiological serum; the extract was filtered and put in the presence of calculi for eight weeks under magnetic agitation. The calculi were weighed biweekly after undergoing a drying process at 40°C for 18 hours, and the pH of the solution was consistently determined. Ammi visnaga, Nigella sativa and Haloxylon scoparium caused significant mass loss and thus had a considerable influence on the dissolution and in vitro inhibition of calcium calculi. In conclusion, this study shows that plants containing coumarins, alkaloids, triterpenes and tannins affect the dissolution and inhibition of kidney stone calcium oxalate.