Romanian Society of Pharmaceutical Sciences
 

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SCREENING OF HETEROCYCLIC SUBSTITUTED SYDNONES FOR POTENTIAL BIOLOGICAL ACTIVITY

NICOLETA OLGUȚA CORNELI 1, FLORIN ALBOTA 2, CRISTIANA CERASELLA DRAGOMIRESCU 1,3, MICHAELA DINA STANESCU 4*

1.“Cantacuzino” National Institute of Research, 103 Splaiul Independenței, 050096, Bucharest, Romania
2 .“C. D. Nenițescu” Centre of Organic Chemistry, 202 Splaiul Independenței, 060021 Bucharest, Romania
3 .“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
4 .“C. D. Nenițescu” Department of Organic Chemistry, Faculty of Applied Chemistry and Material Science, POLITEHNICA University, 1-7 Polizu Street, 011061, Bucharest, Romania

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Nowadays, the emergence of bacterial resistance to antibiotics has become a major public health concern; therefore the development of new compounds overcoming the bacterial resistance is essential. Thus, this study evaluates the in vitro antimicrobial activity of some recently synthesized sydnone derivatives, on Gram-positive (Staphylococcus aureus, Bacillus subtilis), Gram-negative (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa) bacteria and fungi (Candida albicans, Aspergillus niger) and estimates the influence of sub-inhibitory concentrations of these newly synthesized compounds on the expression of some virulence factors by bacterial strains and on adhesion ability to inert substrates.