Romanian Society of Pharmaceutical Sciences
 

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PLGA-BISPHOSPHONATES CONJUGATED NANOPARTICLES: SYNTHESIS AND MORPHOLOGICAL CHARACTERIZATION

ROBERTO ANGELO POSTELNICU 1, MARIA VIORICA CIOCÎLTEU 2*, IONELA ANDREEA
NEACȘU 3, CLAUDIU NICOLICESCU 4, ALEXANDRA COSTACHI 1, MANUEL AMZOIU 1,
JOHNY NEAMȚU 1, CĂTĂLINA GABRIELA PISOSCHI 1, ANDREEA GABRIELA MOCANU 1, GABRIELA RĂU 1, EMILIA AMZOIU 1

1University of Medicine and Pharmacy of Craiova, Petru Rareș Street, 200638, Craiova, Romania
2 Postdoctoral researcher, University of Medicine and Pharmacy of Craiova, Petru Rareș Street, 200638, Craiova, Romania 3Faculty of Chemical Engineering and Biotechnologies, Politehnica University of Bucharest, 1-7 Polizu Street, 011061, Bucharest, Romania
4 Department of Engineering and Management of the Technological Systems, Faculty of Mechanics, University of Craiova, 1 Călugăreni Street, 220037, Drobeta Turnu-Severin, Romania

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The aim of our study was to develop a more advanced method of using some already existing drugs by synthesizing a multicomponent biopolymeric nanocomposite material, which would function as a local drug release system. Thus, we started from simple polylactic-co-glycolic acid (PLGA) nanoparticles, synthesized by the double emulsion method. Then we functionalized the surface of the obtained material with polydopamine (PDA) to which we bound bisphosphonates (used in the current medical practice for the treatment of osteosarcoma). This resulted in a composite material with improved properties compared to constituent materials. The synthesized polymer biocomposites were characterized by SEM (morphological aspects) and Diffusion Light Scattering (DLS) (granulometric dimensions, zeta potential). The chosen synthesis method is simple, inexpensive, with easily adjustable parameters. The theoretical studies carried out regarding the bisphosphonate-polydopamine interaction showed a better stability for the risedronate interaction complex which agrees with the experimental data obtained for it.