Romanian Society of Pharmaceutical Sciences
 

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LOCAL ANTINOCICEPTIVE EFFECT OF “SNOW MOUNTAIN GARLIC” IN AN EXPERIMENTAL FORMALIN MODEL

ANGEL ANTONIO VÉRTIZ-HERNÁNDEZ 1*, PATRICIA PONCE-PEÑA 2, YOLANDA TERÁNFIGUEROA 3, AMAURY DE JESÚS POZOS-GUILLÉN 4, RAQUEL ÁVILA RODRÍGUEZ 1, JUAN ALBERTO VÉRTIZ HERNÁNDEZ 5, AZAHEL DE JESÚS RANGEL-LÓPEZ 1, GABRIELA
MARGARITA MONTERO-MORÁN 6

1Region Altiplano Academic Coordination, Universidad Autónoma de San Luis Potosí, Matehuala, S.L.P., México
2 Faculty of Chemical Sciences, Universidad Juárez del Estado de Durango, Durango, D.G.O., México
3 Faculty of Nursing and Nutrition, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S. L. P., México
4 Faculty of Dentistry, Universidad Autónoma de San Luis Potosí, S.L.P., México
5 Faculty of Sciences, Universidad Autónoma de San Luis Potosí, S.L.P., México
6 Faculty of Chemical Sciences, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S. L. P., México

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Medicinal plants are currently employed for curative purposes in developing and developed countries. One example is garlic (Snow mountain garlic, also called “Himalayan garlic”), used for its multiple therapeutic properties since ancient times. The local Himalayan population generally consumes it as a remedy for rheumatoid arthritis. This study aimed to evaluate the antinociceptive and anti-inflammatory effect of a “Snow mountain garlic” extract in a formalin test. Nociception was measured (number of paw flinches/shakes during one h for 5 min periods), under the administration of 50 µL with formalin 5%, saline solution 0.9%, Snow mountain essential oil 500 µg/kg, diclofenac 250 µg/kg, naproxen 400 µg/kg, and tramadol 500 µg/kg in independent groups. Snow mountain garlic extract has an antinociceptive effect on Phase 2 of the formalin test, which is associated with the inflammatory component of pain, and its behaviour is comparable to that of traditional NSAIDs used in the clinic.