Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF THERAPEUTIC POTENTIAL OF CANNABIDIOLBASED PRODUCTS IN ANIMAL MODELS OF EPILEPTIC SEIZURES, NEUROPATHIC PAIN AND CHRONIC INFLAMMATION

NICOLETA MIRELA BLEBEA 1, DRAGOȘ PAUL MIHAI 2*, CORINA ANDREI 2, DORA
MIHAELA STOICA 2, CORNEL CHIRIȚĂ 2, SIMONA NEGREŞ ²

¹“Ovidius” University of Constanța, Faculty of Pharmacy, 6 Căpitann Aviator Al. Şerbănescu Street, 900470, Constanța,
Romania
2 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Traian Vuia Street 6, 020956, Bucharest, Romania

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Cannabidiol (CBD) is one of the main cannabinoids (CBi) found in Cannabis species. The purpose of this study is to present the evaluation of the anticonvulsant effect in an animal model of epileptic seizures induced by the administration of electric shocks to mice for acute treatment with 3 vegetable oils with CBD. We also evaluated the antihyperalgic effect in a neuropathy model, and anti-inflammatory and analgesic potential of the CBD-containing emulsion after local administration. Significant anticonvulsant and antihyperlagic effects were observed for CBD-containing oils.