Romanian Society of Pharmaceutical Sciences
 

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ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME 2-AND 1,2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

FLORIN AONOFRIESEI 1#, IRINEL-GRAȚIELA MĂNESCU 2#, GABRIELA STANCIU 2*, SIMONA LUPȘOR 2#, MANUELA GHICA 3, MAGDALENA MITITELU 3

1“Ovidius” University of Constanța, Department of Natural Sciences, Faculty of Natural Sciences and Agricultural Sciences, 1 University Street, 900470, Constanța, Romania
2 “Ovidius” University of Constanța, Department of Chemistry and Chemical Engineering, Faculty of Applied Sciences and
Engineering, 124 Mamaia Boulevard, 900527, Constanța, Romania
3 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania

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Benzimidazoles are a large class of compounds with many clinical and pharmacological applications. At present, there is an intense and renewed effort to synthetize new derivatives starting from the well-known benzimidazole moiety and to explore their properties. Due to the increasing antibiotic resistance of pathogens, a major objective is to find new efficient anti-bacterial agents. In this context, the study was carried out in order to estimate the antimicrobial potential of four 2- and 1,2- substituted benzimidazole derivatives already known to have photoprotective properties. Their antimicrobial capacity was assessed by diffusimetric tests by using 13 bacterial and 7 Candida strains and further completed by Minimum Inhibitory Concentration (MIC), and time-kill assay. The mean values of MIC varied between a minimum of 87.5 µg/mL and a maximum of 200 µg/mL in the Staphylococcus group, while for Candida values between 104.6 µg and 151.78 µg/mL were recorded. The results demonstrate a significant inhibitory activity against Gram-positive bacteria and Candida strains. Experiments of time-kill carried out on Candida showed a concentration-dependent activity pattern.