Romanian Society of Pharmaceutical Sciences
 

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PHYSICO-CHEMICAL CHARACTERIZATION OF THE ANTIOXIDANT MIXTURE RESVERATROL-FERULIC ACID FOR APPLICATIONS IN DERMATO-COSMETIC PRODUCTS

DELIA TURCOV 1#, SIMONA BARNA 1*, LENUȚA PROFIRE 2, ANDREEA TEODORA IACOB 2#,
GABRIELA LISĂ 1, ADRIAN-CĂTĂLIN PUIȚEL 1, ANCA ZBRANCA 3, DANIELA ȘUTEU 1#

1Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University from Iași, 700050, Iași, Romania
2 Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania 3Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania

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The aim of the paper was to identify the best combination of resveratrol - ferulic acid with the purpose of increasing the antioxidant activity and maintaining the qualities of resveratrol in the management of skin disorders. Aqueous solutions of resveratrol (1%, 3% and 5% concentrations) and hydro alcoholic solution (30%) of ferulic acid were used. The following resveratrol - ferulic acid mixtures (v/v) were considered: 1:1; 1:2; 1:3 and 1:4. The antioxidant activity of the mixtures was determined and compared with that of resveratrol, and also the physico-chemical were performed by thermogravimetric analyses and UV-VIS spectrophotometry. The results underline that the mixtures of 1% and 3% resveratrol with 0.5% ferulic acid in a ratio of 1:1 and 1:2 ensure the improvement of the antioxidant activity of resveratrol.