Romanian Society of Pharmaceutical Sciences
 

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PLANT PRODUCTS AND THEIR INHIBITORY ACTIVITY AGAINST XANTHINE OXIDASE

USAMAH SAYED 1, MOHAMMAD HUDAIB 2,3, ALA ISSA 3, KHALED TAWAHA 3, YASSER BUSTANJI 4,5*

1Department of Biological Sciences, School of Science, The University of Jordan, Amman, Jordan
2 College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi 112612, UAE
3 School of Pharmacy, The University of Jordan, Amman, Jordan
4 Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE 5Hamdi Mango Center for Scientific Research, The University of Jordan, Amman, Jordan

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Plant phytochemicals are very extensive and varied sources for medicinal compounds. The need for finding alternative remedies for several illnesses that are linked to the products of an enzyme like xanthine oxidase, motivates researchers to find in nature searching for local new better remedies. Many plants’ extracts are investigated, and many other sources like honey, food, and bacteria are being found to produce inhibitors of xanthine oxidase. Yet efforts are needed to find the perfect remedy with clinical effect and with no or little side effects. The aim of this review is to provide recent information on natural substances derived from plants that have the potential to inhibit xanthine oxidase, with attention to some medicinal plants from Jordan. As a consequence of the information presented in this review, several natural compounds have demonstrated to xanthine oxidase inhibitory effects which highlight them as potential candidates for application in the management of different chronic disorders.