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PRELIMINARY RESEARCH REGARDING CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY EFFECTS OF POLYGONUM PLEBEIUM R. BR

HASEEB AHSAN 1*, MUHAMMAD NAVEED MUSHTAQ 2, IRFAN ANJUM 2, MUHAMMAD FIAZ 3, AHMED RAZA CHEEMA 4, SYED IHTISHAM HAIDER 5, GEBRETSADKAN HINTSA TEKULU 6

1Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Pakistan
2 Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Pakistan
3 Faculty of Pharmacy and alternative medicine, The Islamia University of Bahawalpur, Pakistan
4 Department of Economics, Faculty of Social Sciences, University of Sargodha, Pakistan
5 Department of Pharmacology, Nawaz Sharif Medical College, University of Gujrat, Pakistan
6 Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871,
Mekelle, Ethiopia

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Polygonum plebeium is a medicinal plant, traditionally used to treat diseases associated with inflammation. The purpose of this study was to assess the anti-inflammatory effect of the aqueous methanolic extract of Polygonum plebeium (AMEPP). The plant inhibitory potential against protein denaturation was determined by measuring the absorbance of the plant extract treated with bovine serum and egg albumin solutions. The pant in vivo anti-inflammatory activity was examined by using carrageenan and egg albumin induced paw oedema models. The AMEPP has inhibited the egg albumin and bovine serum albumin denaturation (72.99% and 67.51%, respectively) dose depending. The plant extract has significantly reduced inflammation (48.7% and 40.63%, respectively) against carrageenan and egg albumin-induced paw oedema models. The present study concludes that the AMEPP has a promising anti-inflammatory effect which could be related to the presence of the secondary metabolites. The current study confirmed the traditional use of P. plebeium extract in inflammatory conditions.