Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 4/2021

A NEW BROMELAIN-ENRICHED PROTEOLYTIC ENZYMES CONCENTRATE TREATMENT IN PATIENTS WITH EXTENSIVE BURNS: ROMANIAN CONSENSUS

SILVIU ADRIAN MARINESCU 1, CĂTĂLIN GHEORGHE BEJINARIU 1*, BOGDAN MARINESCU 2, ILEANA BOIANGIU 3, TASKOV PANCHE 4, RADU BUDURCA 5, IONEL BOTNARU 6, MARIUS CIUREA 7

1“Carol Davila” University of Medicine and Pharmacy, Department of Plastic and Reconstructive Surgery, Paediatric Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, 12 Berceni Road, 041915, Bucharest, Romania
2 “Carol Davila” Military Emergency University Hospital, Department of Plastic and Reconstructive Surgery, 134 Calea Plevnei Street, 010825, Bucharest, Romania
3 Clinical Emergency Hospital for Plastic Surgery, Reconstructive Surgery and Burns, 218 Calea Griviței Street, 010713,
Bucharest, Romania
4 Timișoara Plastic Surgery Clinic “Casa Austria”, 156 Liviu Rebreanu Boulevard, 300723, Timișoara, Romania 5“Sf. Spiridon” County Emergency Hospital, Department of Plastic and Reconstructive Surgery, Iași, Romania
6 County Emergency Clinical Hospital Oradea, Department of Plastic and Reconstructive Surgery, Oradea, Romania
7 Clinical Emergency County Hospital Craiova, Department of Plastic and Reconstructive Surgery, 1 Tabaci Street, 200642 Craiova, Romania

Download Full Article PDF

In the light of the recent studies, enzymatic debridement is associated with an increased safety profile, an enriched capacity for selective debridement of burn injuries, a significant reduction of blood loss during therapy and a marked decrease of the classical surgical excisions needs. In order to evaluate the results, to establish and extend the indications of enzymatic debridement (ED), a national meeting was organized, with experts who have gained significant experience regarding the use of enzymatic debridement during the therapeutic protocol of burned patients. The main objective of the meeting was to establish a national consensus regarding the enzymatic debridement based on the experience gained during the treatment of 342 patients within 7 Romanian health units. The consensus panel included Romanian experts with an extended experience in treating burns. The following parameters were analysed: optimal time for application, the used technique, pain management, and recommended behaviour after debridement, relationship between enzymatic debridement and grafting, analysis of haematological parameters, learning curve and learning technique. This consensus paperwork may attend as initial testimonial for the employment of enzymatic debridement with user-oriented references until forward proof and formal guiding principle are available.