Romanian Society of Pharmaceutical Sciences
 

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HISTAMINERGIC CONTROL OF THE IRIDAL VASOMOTRICITY IN ALBINO RATS

DRAGOȘ CONSTANTIN LUNCĂ 1#, OANA ANDREIA COMAN 1#, HORIA PĂUNESCU 1*,
CONSTANTIN ȘTEFANI 2, LAURENȚIU COMAN 3, ION FULGA 1#

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Department of Family Medicine, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 Department of Physiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

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The study aimed to investigate the iridal vasomotricity by conjunctival administration of histamine and H1 or H2 antagonists. With the approval of the Institutional Ethics Committee, the right eyes of rats, divided in 5 groups, were examined for 11 minutes. The substances, administered at 30 and 330 seconds, after the beginning of tests, were distilled water and histamine 2.5 mM, 5 mM, or 10 mM respectively; olopatadine 2.5 mM followed by histamine 10 mM; ranitidine 2.5 mM followed by histamine 2.5 mM. The measurements of arteries and veins in 10 moments were performed. In the given experimental conditions, the presence of a histaminergic vasodilator tone was shown. In the iridal territory, this tone produced by H1 and H2 receptors was more intense in arteries than in veins. The vasoconstriction observed after histamine administration might be produced by stimulation of histaminergic H3 receptors.