Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF NEW DIPHENYL SULFONE DERIVATIVES

THEODORA-VENERA APOSTOL 1*, CONSTANTIN DRĂGHICI 2, LAURA-ILEANA SOCEA 1,
OCTAVIAN TUDOREL OLARU 3, GABRIEL ȘARAMET 4, CRISTIAN ENACHE-PREOTEASA 5,
ȘTEFANIA-FELICIA BĂRBUCEANU 1

1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
2 “Costin D. Nenițescu” Institute of Organic Chemistry, Romanian Academy, 202B Splaiul Independenței Street, 060023,
Bucharest, Romania
3 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Botany and Cell Biology
Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
4 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Technology and
Biopharmacy Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
5 National Phytosanitary Laboratory, 11 Voluntari Boulevard, 077190, Voluntari, Ilfov, Romania

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Taking into account that the substituted diphenyl sulfone is an important pharmacophore in medicinal chemistry, in this paper, we report the synthesis, characterization, and cytotoxicity evaluation of seven new compounds: six ethyl 1,3-oxazol-5yl carbonates and an acyclic product (ethyl ester of an N-acyl-α-amino acid), containing the arylsulfonylphenyl moiety. The synthesized compounds were characterized by elemental analysis and spectral techniques (UV-Vis, FT-IR, MS, 1H-NMR, 13C-NMR). Their purity was checked by reversed phase HPLC. The cytotoxic effect of new compounds was assessed using Daphnia magna bioassay.