Romanian Society of Pharmaceutical Sciences
 

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OXIDATIVE STRESS AND CYTOKINES’ INVOLVEMENT IN THE OCCURENCE AND PROGRESSION OF DIABETIC COMPLICATIONS IN THE COVID-19 PANDEMIC CONTEXT

MARIANA CORNELIA TILINCA 1,5, IULIAN MERLAN 6*, ANDREEA SALCUDEAN 4,5, IOAN TILEA 2,5, ENIKO NEMES-NAGY 3

1Department of Internal Medicine I, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of
Târgu Mureș, 540142, Romania 2Department of Internal Medicine VIII, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142, Romania
3 Department of Chemistry and Medical Biochemistry, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142, Romania
4 Department of Ethics and Social Sciences, “George Emil Palade” University of Medicine, Pharmacy, Science and
Technology of Târgu Mureș, 540142, Romania
5 Emergency County Clinical Hospital, Târgu Mureș, 540042, Romania
6 County Clinical Hospital of Târgu Mureș, 540072, Romania

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Diabetes mellitus is a metabolic disease presenting growing prevalence worldwide. Oxidative stress is involved in the development of micro- and macrovascular complications in diabetic patients. Several pro-oxidative pathways contribute to the production of reactive oxygen species which can damage different biomolecules and a variety of inflammatory cytokines are also involved in the aggravation of diabetic manifestations. COVID-19 infection enhances oxygen free radical production and intensifies the inflammation, thus has a negative impact on the evolution of diabetes mellitus and its complications. The complications of diabetes including the macrovascular and microvascular conditions as well as the psychological illnesses have a major influence on the patients’ quality of life.