Romanian Society of Pharmaceutical Sciences
 

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THE ROLE OF SERUM IONS DEFICIENCIES IN THE PATHOGENIC MECHANISMS OF ONCOLOGICAL DEPRESSION: PSYCHO-PHARMACOLOGICAL PARTICULARITIES

ADELA MAGDALENA CIOBANU 1,2#, MARA JIDVEIAN POPESCU 3*, MIHNEA COSTIN
MANEA 2,4#, DOINA DRĂGĂNESCU 5#, DUMITRU LUPULIASA 6, DRAGOȘ MARINESCU 7, PUIU OLIVIAN STOVICEK 8

1“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Neuroscience Department, Discipline of
Psychiatry, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2 “Prof dr. Alexandru Obregia” Clinical Psychiatric Hospital, Department of Psychiatry, 10th Berceni Road, 041914,
Bucharest, Romania
3 CF2 Clinical Hospital, Oncology Department, 63 Mărăști Street, 012244, Bucharest, Romania
4 “Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine, Discipline of Psychiatry and Psychology, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
5 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Physics and
Informatics, 6 Traian Vuia Street, 020956, Bucharest, Romania
6 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Technology and
Biopharmaceutics, 6 Traian Vuia Street, 020956, Bucharest, Romania
7 Academy of Medical Sciences of Romania, University of Medicine and Pharmacy of Craiova Brunch, 2 Petru Rareș Street, 200349, Craiova, Romania
8 “Titu Maiorescu” University Bucharest, Faculty of Nursing, Department of Pharmacology, Târgu Jiu Subsidiary, 100
Ecaterina Teodoroiu Avenue, 210106, Gorj County, Romania

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Cancer patients frequently present symptoms of depression and anxiety that influence the quality of life, compliance and adherence to treatment, disease progression and the overall survival. Psychiatric pathology could be related to the disturbance of serum ion levels, caused by the oncological or psychiatric status and the adverse effects of pharmacological treatment. This article is focused on assessing the relationship between anxiety, depression and stress and serum ion levels. Changes in the homeostasis of serum ions and pH may be factors that favour the risk of oncogenesis in the context of this psychiatric pathology. Knowledge of the involvement of serum ions in specific pathogenic mechanisms suggests the importance of monitoring them in oncological pathology with depression and helps to develop personalized psychopharmacological strategies