Romanian Society of Pharmaceutical Sciences
 

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2-AMINO-1,3,4-THIADIAZOLE DERIVATIVES AS POTENTIAL ANTI-HELICOBACTER PYLORI AGENTS – AT A GLANCE

GEORGETA ŞERBAN 1*, IRINA KACSO 2

1.University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga Street, 410028, Oradea, Romania
2 .National Institute for Research and Development of Isotopic and Molecular Technologies, Department of Biomolecular and Molecular Physics, 67-103 Donath Street, 400293, Cluj-Napoca, Romania

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Helicobacter pylori is a major human pathogen that causes gastric and extra-gastric complications and infects around 50% of the global population. Gastric cancer is a serious consequence of H. pylori infection. About 89% of all gastric cancers can be attributed to this pathogen. Treatment is indicated for all infected patients, as a strategy to knock down the risk of gastric malignancy. Due to the high level of antimicrobial resistance, new medicines are needed to treat H. pylori infection. This paper presents 2-amino-1,3,4-thiadiazole derivatives which exhibited anti-H. pylori effect. Some of the reported compounds showed higher activity compared to standard drugs, making the 2-amino-1,3,4-thiadiazole core a possible pattern for future anti-H. pylori agents.