Romanian Society of Pharmaceutical Sciences
 

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CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS.

GÖKÇE ŞEKER KARATOPRAK 1*, LEYLA PAŞAYEVA 1, ESRA KÖNGÜL ŞAFAK 1, FATIH GÖGER 2, OSMAN TUGAY 3, MÜBERRA KOŞAR 4

1.Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey
2 .Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey
3 .Department of Botany, Faculty of Art and Science, Selçuk University, Konya, Turkey
4 .Department of Pharmacognosy, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin-10 Turkey

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Aerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-α (TNF-α) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 ± 15.07 mgGAE/ gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-α production (37.26 μM and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.