Romanian Society of Pharmaceutical Sciences
 

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ANTIOXIDANT AND ANTIMICROBIAL POTENTIAL OF NEW AZETIDIN-2-ONE OF FERULIC ACID

MARIA DRĂGAN 1#, OANA DRAGOSTIN 2#, ANDREEA IACOB 1#, LENUŢA PROFIRE 1#, CĂTĂLINA DANIELA STAN 1*, CRISTINA TUCHILUŞ 3

1.Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România
2 .Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 35 Al. I. Cuza Street, 800216, Galaţi, România
3 .Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România

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The objective of our study was to evaluate the antioxidant and antimicrobial potential for six new azetidin-2-one derivatives of ferulic acid. The in vitro antioxidant potential of the compounds was assessed by using the total antioxidant capacity and total reducing power assays. The antimicrobial activity was investigated using Gram positive bacteria (Staphylococcus aureus ATCC 25923), Gram negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) and pathogenic yeast (Candida albicans ATCC 90028, Candida parapsilosis ATCC 22019). Several of the synthesized compounds showed a good antioxidant activity, exceeding the ferulic acid antioxidant potential. All the investigated compounds proved active against Gram positive bacteria.