Romanian Society of Pharmaceutical Sciences
 

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TESTOSTERONE THERAPY, NEW OPPORTUNITIES IN DIABETES MELLITUS

ANCA PANTEA-STOIAN 1#, SILVIU MIREL PIȚURU 2#*, RĂZVAN HAINĂROȘIE 3#, LILIANA FLORINA ANDRONACHE 4#, OCTAV GINGHINĂ 5#, CRISTIAN SERAFINCEANU 6,7#

1.“Carol Davila” University OF Medicine and Pharmacy, Faculty of Medicine, Departament of Hygiene, 8 Eroii Sanitari Street, Bucharest, Romania
2 .“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Bucharest, Romania
3 .“Carol Davila” University of Medicine and Pharmacy, “Prof. Dr. Dorin Hociotă” Institute of Phonoaudiology and Functional ENT Surgery, 21 Mihail Cioranu Street, Bucharest, Romania
4 .“Carol Davila” University of Medicine and Pharmacy, Department of Foreign Languages, 8 Eroii Sanitari Street, Bucharest, Romania
5 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine, Department of Surgery, “Sf. Ioan” Clinical Emergency Hospital, 13 Vitan-Bârzești Road, Bucharest, Romania
6 .“N. C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Disease, 5-7 Ion Movilă Street, Bucharest, Romania
7 .“Carol Davila" University of Medicine and Pharmacy, Department of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania

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Diabetes mellitus is at the moment a real public health problem worldwide. It is estimated that at least one-third of male patients with type 2 diabetes mellitus also have associated testosterone deficiency. In this context, the opportunity for testosterone medication in patients with hypogonadism and type 2 diabetes mellitus becomes very attractive if we also take into account its pleiotropic effects on the metabolic syndrome. As it has been demonstrated, the low level of testosterone is associated with an increase in cardio-metabolic risks, which lead to increased premature mortality. Testosterone therapy is relatively safe, having potential benefits as long as the cases are carefully selected and its positive effects on the metabolic status recommend this therapy as an interesting option in patients with documented diabetes mellitus and hypogonadism.