Romanian Society of Pharmaceutical Sciences
 

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RELATIONSHIP BETWEEN ADIPONECTIN AND SOME METABOLIC PARAMETERS IN OBESE AND DIABETIC PATIENTS

RAMONA GLIGOR1, MARIA PUŞCHIŢĂ2, DANA ZDREMŢAN1, IOAN CRÎSNIC1, CONSTANTIN IONESCU-TÎRGOVIŞTE3

1Department of Biochemistry,”Vasile Goldiş” Western University, Arad, Henri Coanda, 31, Romania
2 Department of Internal Medicine,”Vasile Goldiş” Western University, Arad, Romania
3 National Institute of Diabetes, Nutrition and Metabolic Diseases N.C.Paulescu, Bucharest

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It was recently discovered that the adipose tissue possesses a secreting role, biosynthesizing a series of bioactive substances that are transported through the blood and modulate the physiology of different organs. In this study, we analyzed the correlation of serum adiponectin with obesity, diabetes and dyslipidemia. We studied a total number of 110 subjects. These were divided into three groups, depending on their metabolic conditions. Group I – 60 patients diagnosed with type 2 diabetes, group II – 30 patients dignosed with obesity and the control group – 20 subjects, healthy, normal weight. Comparing the mean values of adiponectin in diabetic patients with the mean values of adiponectin in the control group, we found that they were statistically significant lower for the diabetic patients (t = 9.56, p<0.0001). Also, in patients from the second group, the adiponectin values were significantly lower when compared to the control group, t=9.13; p<0.001.