Romanian Society of Pharmaceutical Sciences
 

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ACITRETIN TREATMENT IN PSORIAZIS MAY INFLUENCE THE CELL MEMBRANE FLUIDITY

CAROLINA NEGREI1, ANDREEA LETIŢIA ARSENE2, CORINA DALIA TODERESCU3, DANIEL BODA4*, MIHAELA ILIE1

1Department of Toxicology, “Carol Davila” University of Medicine and Pharmacy, 6, Traian Vuia street, Bucharest, Romania
2 Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, Romania
3 ”Vasile Goldis” Western University of Arad, 91-93, L. Rebreanu Str., Arad, Romania
4 Center of Excellence in Dermato-oncology, “Carol Davila” University of Medicine and Pharmacy, 22-24 Gr. Manolescu street, Bucharest, Romania

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Psoriasis is a chronic recurring condition that varies in severity from minor localized patches to complete body coverage. In this disease the normal cycle of replacing old skin cells with new one becomes unbalanced. The most popular parameter to characterise plasma membrane is fluidity. The membrane fluidity in psoriatic patients decreases. The present paper is intended to review the literature data on the possible involvement of membrane fluidity in psoriatic patients; a special focus is given to patients treated with acitretin.