Romanian Society of Pharmaceutical Sciences
 

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SOLID-STATE CHARACTERIZATION OF BIFONAZOLE – RANDOM METHYL-BETACYCLODEXTRIN BINARY SYSTEMS

CRISTINA TRANDAFIRESCU1*, ÁRPÁD GYÉRESI2, ZOLTÁN SZABADAI3, CRISTINA PĂTRUŢESCU1, MIHÁLY KATA4, ZOLTÁN AIGNER4

1Victor Babeş University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 1st Eftimie Murgu Str., Timişoara, România
2 University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 38th Gheorghe Marinescu Str., Târgu-Mureş, România
3 Victor Babeş University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Analysis, 1st Eftimie Murgu Str., Timişoara, România
4 University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, 6th Eötvös Str., Szeged, Hungary

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The aim of this paper was to investigate the interaction in solid state between the antimycotic agent bifonazole with random methyl-β-cyclodextrin. The binary systems between bifonazole and random methyl-β cyclodextrin were prepared in four molar ratios, by two methods. The interaction between the components was characterized by thermal and spectral methods.